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KMID : 0923620140140020107
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Immune Network
2014 Volume.14 No. 2 p.107 ~ p.115
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Phellinus linteus Extract Exerts Anti-asthmatic Effects by Suppressing NF-?B and p38 MAPK Activity in an OVA-induced Mouse Model of Asthma
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Yan Guang-Hai
Choi Yun-Ho
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Abstract
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Phellinus linteus has been used as a traditional herbal medi-cine in Asian countries and is known to have anti-tumor, im-munomodulatory, anti-inflammatory, and anti-allergic activ-ities. However, the protective effects of P. linteus against ex-perimental asthma have not been fully investigated. The ob-jective of this study was to determine whether P. linteus ethanol extract (PLE) suppresses inflammatory response in an OVA-induced asthma model. As expected, the oral admin-istration of PLE significantly inhibited eosinophilic airway in-flammation and airway hyperresponsiveness in OVA-chal-lenged BALB/c mice. Supporting these data, the augmenta-tion of Th2 cytokines (IL-4, IL-5, and IL-13), eotaxin, and ad-hesion molecules in lung tissues and bronchoalveolar lavage fluid after OVA inhalation was markedly attenuated by PLE. Furthermore, PLE reduced OVA-induced activation of NF-?B and p38 MAPK in lung tissues. Therefore, our results sug-gest the potential of P. linteus as a therapeutic agent for asthma.
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KEYWORD
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Phellinus linteus, Asthma, Allergic inflammation, Th2 cytokine, NF-?B, p38
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